You may use Arthro-IonX along with other medications or supplements. It is homeopathic in nature and so it will not negatively interact with other physical substances. Arthro-IonX helps to decrease pain and inflammation and stimulate healing. In addition I find it helpful to follow a holistic approach by giving some nutritional supplements to accompany Arthro-IonX. The supplements I recommend are digestive enzymes with meals, MSM, probiotics, vitamin C, and fish oil. Arthro-IonX will help the body to better utilize the nutrition for a synergistic response. Giving some of the supplements may lessen the need for the amount of insulin you are currently giving so you should monitor blood glucose levels so that you would know whether you need to change the dosage. Please let us know how you do or if you have any other questions.