I would start with DERMA-IONX to help with the hair loss. Having your puppy visit your veterinarian would be helpful to determine if you are dealing with mange, if there is an infection, or allergies. With Demodectic mange it is important to work on the immune system or it might relapse once you finish treatment. DERMA-IONX and PROBIOTICS can help strengthen the immune system.. OMEGA 3,6,9 given orally is helpful for the skin and the developing nervous system. If you do need to bathe the puppy you can use DEFENDEX shampoo but it is important to avoid the area around the eyes. Please let us know if you have any other questions.