You may use Arthro-IonX along with other medications or supplements. So it is OK to use with Thyroxine. It is homeopathic in nature and so it will not negatively interact with other physical substances. Arthro-IonX helps to decrease pain and inflammation and stimulate healing. In addition I find it helpful to follow a holistic approach by giving some nutritional supplements to accompany Arthro-IonX. The supplements I recommend are digestive enzymes with meals, MSM, probiotics, and fish oil. Arthro-IonX will help the body to better utilize the nutrition for a synergistic response. Please let us know how you do or if you have any other questions.