It is OK to use even if your dog has an elevation in liver enzymes. You may use Arthro-IonX along with other medications or supplements. It is homeopathic in nature and so it will not negatively interact with other physical substances. Arthro-IonX helps to decrease pain and inflammation and stimulate healing. In addition I find it helpful to follow a holistic approach by giving some nutritional supplements to accompany Arthro-IonX. The supplements I recommend are digestive enzymes with meals, probiotics, and fish oil. Arthro-IonX will help the body to better utilize the nutrition for a synergistic response. Please let us know how you do or if you have any other questions.